王贞超简介

王贞超，1986年2月，中共党员，教授，博士生导师，农药学理学博士，芝加哥大学、伊利诺伊理工大学、北京大学访问学者、贵州省“科技拔尖”、千层次”创新型人才、高新技术企业认定专家、工信厅科技副总、山东省博兴县科技镇长团成员。聚焦化学生物学、药学、农药学等，开展具有医用农用活性的中草药源杂环先导化合物联合创制研究。现主持或完成国家基金2项、省部级重点项目1项、省部级一般项目3项、地厅级项目6项，作为第一作者或者通讯作者，发表SCI 40篇，申请国家发明专利12项，担任Bioenergy and Biofuel、Frontiers in Agronomy等期刊Review Editor。

邮箱：wzc.4884@163.com 

2020.01-至今，贵州大学，ob体育平台，教授

2020.09-2021.06，北京大学，化学与分子工程学院，访问学者

2018.01-2019.12，贵州大学，ob体育平台，副教授

2018.09-2018.12，芝加哥大学，化学生物学系，访问学者

2018.09-2018.12，美国伊利诺伊理工大学，化学院，访问学者

2015.08-2017.12，贵州大学，ob体育平台，校聘副教授

2008.09-2015.07，贵州大学，农药学，博士

2003.09-2007.03，临沂大学，应用化学，学士

【学术兼职及荣誉称号】

贵州省“科技拔尖”、“千层次人才”、贵州省高新技术企业认定专家、山东省博兴县科技镇长团成员、贵州大学卓越基金奖励（青年教师类）二等奖、优秀本科生导师、“溪山先锋”、“青年教学能手”、“身边榜样”、优秀教师、贵州大学教学成果奖二等奖、贵州大学学术带头人培育对象等。

【主持项目】

    1.国基青年基金：高效抗水稻白叶枯病菌活性喹唑啉化合物的作用靶标研究

    2.国基地区基金：含吡啶基喹唑啉酮类化合物C1抑制柑橘溃疡病菌作用靶标及机制研究

    3.贵州省科技拔尖、贵州省千层次创新人才项目

    4.贵州省基金（重点项目）：基于活性表达谱策略（Activity-Based Protein Profiling Technique）开展高效抗水稻白叶枯病菌喹唑啉化合物的作用靶标研究

    5.贵州省基金：基于EGFR亲和活性评价模型筛选贵州中草药源抗肿瘤活性成分

    6.贵州省基金：靶向p53蛋白的小分子化合物筛选研究

    7.绿色农药与农业生物工程国家重点实验室培育基地教育部重点实验室开放基金：吲哚3位稠环取代衍生物的合成及抑制水稻白叶枯病菌的生物活性研究

    8.贵州医科大学药用植物功效利用国家重点实验室开放项目：源于天然产物的吲哚类化合物合成及其抗肿瘤活性研究

    9.省教育厅基金：基于EGFR虚拟筛选的喹唑啉衍生物的合成及其抗肿瘤活性研究

    10.贵州大学人才引进基金1项，贵州大学实验室开放课题1项

    11.教改项目：CDIO模式无机化学课程双语教学模式改革

    12.教改项目：药物蛋白质工程

【近期发表论文】     

    1.Wang, Z. C.; Yu, D. D.; Li, X. Y.; Zeng, M. J.; Chen, Z.; Bi, L.; Liu, J. J.; Jin, L. H.; Hu, D. Y.; Song, Y.*; Song, B. A.* The Development and application of a Dot-ELISA aassay for diagnosis of southern rice black-Streaked dwarf disease in the field [J] Viruses, 2012, 4, 167−183.

     2.Yu, D. D. #; Wang, Z. C.#; Liu, J.; Lv, M. M.; Liu, J. J.; Li, X. Y.; Chen, Z.; Jin, L. H.; Hu, D. Y.; Song, Y.; Song, B. A.* Screening anti-southern rice black-streaked dwarf virus drugs based on S7‑1 gene expression in rice suspension cells [J] Journal of Agricultural and Food Chemistry, 2013, 61, 8049−8055.

    3.Wang, Z. C.; Li, X. Y.; Wang, W. L.; Zhang, W. Y.; Yu, L.; Hu, D. Y.; Song, B. A.* Interaction research on the antiviral molecule dufulin targeting on southern rice black streaked dwarf virus P9-1 nonstructural protein [J] Viruses, 2015, 7, 1454−1473.

    4.Wang, Z. C. #; Yu, L. #; Jin, L. H.; W. L.; Zhao, Q.; Ran, L. L.; Li, X. Y.; Chen, Z.; Guo, R.; Wei, Y. T.; Yang, Z. C.; Liu, E. L.; Hu, D. Y.; Song, B. A.* Evaluation of rice resistance to southern rice black-streaked dwarf virus and rice ragged stunt virus through combined field tests, quantitative real-time PCR, and proteome analysis [J] Viruses, 2017, 9, 37; doi:10.3390/v9020037.

    5.Le, Y. #; Gan, Y. Y. #; Fu, Y. H.; Liu, J. M.; Li, W.; Xue, Z.; Zhou, Z. X.; Wang, Z. C.* & Ouyang G. P.* Design, synthesis and in vivo biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment [J] Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35(1): 555−564.

    6.Shao, L. H. #; Fan, S. L. #; Meng, Y. F.; Gan, Y. Y.; Shao, W. B.; Wang, Z. C.*; Chen, D. P.*; Ouyang, G. P.* Design, synthesis, biological activities and 3D-QSAR studies of quinazolinone derivatives containing hydrazone structural units [J] New Journal of Chemistry, 2021, 45, 4626−4631.

    7.Zhou, X.; Liu, J. M.; Meng, J.; Fu, Y. H.; Wu, Z. B.; Ouyang, G. P.; Wang, Z. C.* Discovery of facile amides-functionalized rhodanine-3-acetic acid derivatives as potential anticancer agents by disrupting microtubule dynamics [J] Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36, 1996−2009.

    8.Rong, Z. Q.; Wang, X. C.; Wang, Z. C.*; Liu, P. F.; Rong, Z. Q.* Redox-neutral remote amidation of alkenyl alcohols via long-range isomerization/transformation [J] Organic Chemistry Frontiers, 2022, 9: 5942−5948.

    9.Zhu, M.; Long, X. S.; Wang, C. Y.; Ouyang, G. P.*; Wang, Z. C.* Antibacterial activity of allicin-inspired disulfide derivatives against xanthomonas axonopodis pv. citri. [J] International Journal of Molecular Sciences, 2022, 23, 11947.

    10.Zhou, X.; Fu, Y. H.; Zhou, Y. Y.; Meng, J.; Ouyang, G. P.*; Wang, Z. C.* Discovery of simple diacylhydrazine-functionalized cinnamic acid derivatives as potential microtubule stabilizers [J] International Journal of Molecular Sciences, 2022, 23, 12365.

    11.Zhu, M.; Li, Y.; Chen, D. P.; Li, C. P.; Ouyang, G. P.*; Wang, Z. C.* Allicin-inspired disulfide derivatives containing quinazolin-4(3H)-one as a bacteriostat against Xanthomonas oryzae pv. oryzae [J] Pest Management Science. 2023, 79: 537−547.

    12.Zou, Y. Y.; Zhang, G. L.; Li, C. P.; Long, H. T.; Chen, D. P.; Li, Z. R.; Ouyang, G. P.; Zhang, W. J.; Wang, Z. C.* Discovery of tryptanthrin and its derivatives and its activities against NSCLC in vitro via both apoptosis and autophagy pathways [J] International Journal of Molecular Sciences, 2023, 24, 1450.

    13.Zhang, G. L.; Tang, Z. H.; Fan, S. L.; Li, C. P.; Li, Y.; Liu, W. Q.; Long, X. S.; Zhang, W. J.; Zhang, Y.; Li, Z. R.; Wang, Z. C.*; Chen, D. P.; Ouyang, G. P. Synthesis and biological assessment of indole derivatives containing penta-heterocycles scaffold as novel anticancer agents towards A549 and K562 cells [J] Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38(1): 2163393.

    14.Shao, L. H.; Zhao, S.; Yang, S.; Zhou, X.; Li, Y.; Li, C. P.; Chen, D. P.; Li, Z. R.; Ouyang, G. P.; Wang, Z. C.* Design, synthesis, antibacterial evaluation, three-dimensional quantitative structure−activity relationship, and mechanism of novel quinazolinone derivatives [J] Journal of Agricultural and Food Chemistry, 2023, 71: 3939−3949.

    15.Zhang, G. L.; Li, C. P.; Li, Y.; Chen, D. P.; Li, Z. R.; Ouyang, G. P.*; Wang, Z. C.* Discovery and mechanism of azatryptanthrin derivatives as novel anti-phytopathogenic bacterial agents for potent bactericide candidates [J] Journal of Agricultural and Food Chemistry, 2023, doi.org/10.1021/acs.jafc.3c01120.